Table 8.
Gene ontology-based general and ovary-specific functional enrichment of all target genes of differentially expressed miRNAs.
| General Analysis 1 | Ovary-Specific Analysis | ||
|---|---|---|---|
| GO Biological Process | P Value | GO Biological Process | P Value |
| Phosphatidylinositol-mediated signaling | 4.5190 × 10−11 | Phosphorylation | 4.62 × 10−61 |
| TGFβ receptor signaling pathway | 1.9554 × 10−8 | Regulation of protein modification process | 1.14 × 10−51 |
| MAPK cascade | 4.6884 × 10−7 | Regulation of transferase activity | 2.69 × 10−46 |
| Peptidyl-Tyr-phosphorylation | 6.050 × 10−7 | Regulation of kinase activity | 2.5 × 10−45 |
| Phosphatidylinositol 3-kinase signaling | 7.1633× 10−7 | Enzyme linked receptor protein signaling | 1.45 × 10−43 |
| Positive regulation of Tyr- phosphorylation of Stat3 protein. | 9.8981 × 10−7 | Regulation of cell cycle | 1.46 × 10−41 |
| I-κB kinase/NF-kappaB signaling | 2.9099 × 10−6 | Regulation of protein kinase activity | 6.19 × 10−41 |
| IL6-mediated signaling pathway | 5.8361 × 10−6 | Cell proliferation | 2.65 × 10−40 |
| Positive regulation of pri-miRNA transcription | 1.2812 × 10−7 | Cellular response to stress | 1.15 × 10−37 |
| Positive regulation of EMT | 2.7940 × 10−5 | Intracellular protein kinase cascade | 2.57 × 10−37 |
| JNK cascade | 5.6629 × 10−5 | Cell cycle | 3.26 × 10−37 |
| Response to calcium ion | 1.4710 × 10−4 | Positive regulation of RNA metabolic process | 1.38 × 10−36 |
| SMAD protein signal transduction | 2.0946 × 10−4 | Regulation of programmed cell death | 3.09 × 10−35 |
| Insulin signaling pathway | 2.0956 × 10−4 | Positive regulation of signal transduction | 4.45 × 10−35 |
| T cell receptor signaling pathway | 2.9929 × 10−4 | Regulation of cell proliferation | 1.18 × 10−34 |
| Positive regulation of GTPase activity | 8.5273 × 10−4 | Negative regulation of apoptotic process | 6.4 × 10−34 |
| Toll-like receptor signaling pathway | 9.5585 × 10−4 | Intracellular signal transduction | 8.73 × 10−34 |
| Cell-matrix adhesion | 0.0010 | Reproduction | 8.6 × 10−33 |
| Heterotypic cell-cell adhesion | 0.0012 | Negative regulation of transcription | 1.78 × 10−32 |
| SMAD protein complex assembly | 0.0017 | Negative regulation of nucleobase_containing compound metabolic process | 3.1 × 10−29 |
1 In general analysis tissue specific expression is not considered.