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. 2019 Sep 7;11(9):2144. doi: 10.3390/nu11092144

Figure 1.

Figure 1

Influence of TP53 induction on total intracellular iron levels. TP53 null H1299 cells (H1299) were transfected with either a tetracycline inducible wild-type (WT) TP53 or a representative contact (R237H or R248Q) or conformational (R175H or H193Y) mutant TP53. (A) Western blot of TP53 expression levels in each following tetracycline induction. (B) Relative CDKNA1A mRNA expression levels following tetracycline induction of WT TP53 and indicated TP53 mutants. (C) Total intracellular iron was differentially altered in response to the induction of distinct TP53 mutation types. * Denotes statistical difference from H1299, p < 0.05.