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. 2019 Aug 22;8(9):956. doi: 10.3390/cells8090956

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed mechanism of RGC survival and axon regeneration by GSK3β and RTP801. RGC survival is signalled through the mTORC1 pathway downstream of GSK3β, whilst axon regeneration is signalled independently by mTOR and GSK3β pathways. The question mark and the red arrow represent unknown effectors downstream of GSK3β.