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The characteristics of cecal ligation and puncture sepsis surgery after LPS tolerance induction by sequential LPS stimulation (CLP after LPS/LPS) (see method) in wild-type (WT) and FcGRIIb-/- mice with and without recombinant Lcn-2 (rLcn-2) administration as evaluated by survival analysis (A) and serum markers of injury including serum creatinine (B), alanine transaminase (C) and cytokines (D–F) (n = 7–10/group for B–F) were demonstrated. *, p < 0.05.
