Table 2.
The most significant 10 upstream transcription factors (TFs) regulating the upregulated DEmiRs and the most significant 10 upstream TFs regulating the downregulated DEmiRs.
| Change of DEmiRs | Upstream TFs | p-Value (Hypergeometric Test) |
|---|---|---|
| Upregulated | EGR1 | 6.50 × 10−37 |
| SP1 | 5.36 × 10−29 | |
| SP4 | 6.01 × 10−26 | |
| NKX6-1 | 5.19 × 10−22 | |
| POU2F1 | 3.44 × 10−21 | |
| MEF2A | 3.64 × 10−18 | |
| RREB1 | 1.41 × 10−17 | |
| ZFP161 | 1.94 × 10−16 | |
| NFIC | 2.61 × 10−15 | |
| ONECUT1 | 1.90 × 10−14 | |
| Downregulated | SP4 | 1.30 × 10−17 |
| SP1 | 3.82 × 10−17 | |
| EGR1 | 3.85 × 10−15 | |
| HOXA5 | 1.43 × 10−8 | |
| PDX1 | 1.92 × 10−8 | |
| KLF7 | 3.18 × 10−8 | |
| RORA | 3.62 × 10−8 | |
| POU2F1 | 3.98 × 10−8 | |
| TCF3 | 9.19 × 10−8 | |
| FOXD3 | 3.27 × 10−7 |