Figure 2.

Quercetin inhibits the crosstalk between signal transducer and activator of transcription 3 (STAT3) and interleukin-6 (IL-6) in EBV-infected cells. (a) Western blot analysis of STAT3 705 Tyr phosphorylation evaluated following EBV infection of B cells in the presence or absence of quercetin at 24 and 72 h post-infection. Densitometric analysis was performed using Image J software, and the ratio of p-STAT3 vs. STAT3 or of STAT3 versus β-actin, was calculated. Histograms represent the mean ± SD of three independent experiments. (b) IL-6 release by EBV-infected cells in the presence or in the absence of quercetin at 24 and 72 h. Histograms represent the mean ± standard deviation (SD) of IL-6 release (pg/mL) from three independent experiments.