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Protective effects of DDAHs. Solid lines—proven effects. Dashed lines—hypothesized effects. DDAH1 lowers ADMA, which leads to elevation in NO bioavailability and protects from cardiovascular injury. The relative contribution of DDAH2 to ADMA clearance is still not entirely clear. Both DDAH1 and DDAH2 have been shown to have ADMA-independent effects.
