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Time spent in center and peripheral zones of the open field test. Data presented as mean ± SEM. * p < 0.05 compared to center zone. Saline + Saline (n = 11), 5-FU + Saline (n = 12), 5-FU + Fentanyl (n = 12), 5-FU + Morphine (n = 12) and 5-FU + Oxycodone (n = 12).
