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. 2019 Sep 13;20(18):4545. doi: 10.3390/ijms20184545

Figure 4.

Figure 4

Melatonin increases the numbers of healthy mitochondria by stabilizing parkin in hMSCs subjected to oxidative stress. (A) Mitochondrial morphology was evaluated using TEM in hMSCs treated with melatonin (1 μM, 24 h) and si-HSPA1L, and subjected to oxidative stress. Scale bar = 500 nm. (B,C) Quantitative analyses of morphometric data, and percentages of abnormal mitochondria showing swelling and severely disrupted cristae, as evaluated using TEM. Values represent the mean ± SEM. * p < 0.05, and ** p < 0.01 vs. untreated hMSCs; ## p < 0.01 vs. melatonin–treated hMSCs; $ p < 0.05, and $$ p < 0.01 vs. melatonin-treated hMSCs pretreated with si-HSPA1L.