Table 7.

Meta-analyses of height-for-age z-scores in children with mild hyperphenylalaninemia.

Age (Year)	NoS a	NoP Tested	Effect Size	Heterogeneity I2, P	95% CI	P
0	2	256	−0.161	I2 = 93.4%, P < 0.0001	−0.780 to +0.458	0.610
1	2	257	−0.236	I2 = 86.7%, P = 0.006	−0.588 to +0.116	0.189
2	2	255	−0.255	I2 = 75.6%, P = 0.043	−0.541 to 0.031	0.081
3	2	252	−0.140	I2 = 0.0%, P = 0.477	−0.184 to −0.096	<0.0001
4	2	253	−0.298	I2 = 88.4%, P = 0.003	−0.775 to +0.180	0.222
5	2	253	−0.246	I2 = 91.9%, P = 0.0005	−0.889 to +0.397	0.453
6	2	247	−0.183	I2 = 86.7%, P = 0.006	−0.730 to +0.365	0.513
7	2	243	−0.047	I2 = 89.0%, P = 0.003	−0.846 to +0.753	0.909
8	2	240	−0.123	I2 = 75.6%, P = 0.043	−0.719 to +0.473	0.687
9	2	238	−0.069	I2 = 71.2%, P = 0.063	−0.617 to +0.478	0.804
10	2	234	−0.333	I2 = 78.4%, P = 0.031	−1.124 to +0.458	0.409
11	2	235	−0.134	I2 = 47.9%, P = 0.166	−0.540 to +0.273	0.519
12	2	234	−0.288	I2 = 0.0%, P = 0.980	−0.385 to −0.191	<0.0001

NoS: number of studies; NoP: number of patients; CI: confidence interval. References: ^a Aldámiz-Echevarría et al., 2014 [31], Thiele et al., 2017 [32].