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. 2019 Sep 16;20(18):4575. doi: 10.3390/ijms20184575

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Suppression of P-gp activity induced by Hsp90 inhibitors. (a) The inhibition of P-gp activity in MDR NCI-H460/R and DLD1-TxR cells after 30 min treatment with Hsp90 inhibitors. (b) Dose dependent effects on P-gp inhibition in NCI-H460/R and DLD1-TxR cells after 30 min treatment with Hsp90 inhibitors. Tariquidar (TQ) is included as positive control. The results are expressed as mean ± SD. Statistical significance to untreated control from three independent experiments: p < 0.05 (*), p < 0.001 (***).