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. 2019 Sep 16;20(18):4575. doi: 10.3390/ijms20184575

Figure 4.

Figure 4

Changes in P-gp expression at protein level after treatment with Hsp90 inhibitors. Changes in P-gp expression in (a) parental NCI-H460 cell line, (b) MDR NCI-H460/R cell line, (c) parental DLD1 cell line and (d) MDR DLD1-TxR cell line after 72 h treatment with compounds 5, 7 and 9. Doxorubicin DOX, paclitaxel (PTX) and tariquidar (TQ) are included as positive controls. The results are expressed as mean ± SEM. Statistical significance to untreated control from three independent experiments: p < 0.05 (*), p < 0.01 (**), p < 0.001 (***).