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Relative reversal of doxorubicin (DOX) and paclitaxel (PTX) resistance in NCI-H460/R and DLD1-TxR cells induced by Hsp90 inhibitor.
| Compound | DOX IC50 (nM) | Relative Reversal |
|---|---|---|
| DOX | 2265.6 ± 42.4 | |
| 5 | ||
| 2.5 µM | 1731.4 ± 30.9 | 1.31 |
| 5 µM | 863.9 ± 25.6 | 2.62 |
| 10 µM | 429 ± 13.3 | 5.28 |
| PTX | 1528.5 ± 48.6 | |
| 5 | ||
| 1 µM | 850.4 ± 13.1 | 1.80 |
| 2.5 µM | 588.3 ± 12.0 | 2.60 |
| 5 µM | 290.0 ± 5.0 | 5.27 |
