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. 2019 Aug 24;9(9):409. doi: 10.3390/biom9090409

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Main metabolites of Trp and their detection in the two cell lines studied, MCF-7 (blue) and A375 (red). Metabolite detection was done by LC-MS, except for serotonin which was detected by HPLC. MCF-7 breast cancer cells metabolize more extensively Trp than A375 melanoma cells, as shown by the larger series of Trp metabolites identified in the medium of MCF-7 cells. TDO: tryptophan 2,3-dioxygenase; IDO: indoleamine 2,3-dioxygenase; KAT: kynurenine aminotransferase; KYNU: kynureninase; 3-HAO: 3-hydroxyanthranilate oxidase.