Table 2.
Results of the micronucleus assay on L5178Y mouse lymphoma cells.
| Dose (µM) | Relative % of Survival | Total Number of Micronuclei for 2000 Mononuclear Cells | Relative % of Survival | Total Number of Micronuclei for 2000 Mononuclear Cells | |
|---|---|---|---|---|---|
| without recovery | with recovery | ||||
| without metabolic activation | untreated | 100 | 3 | 100 | 3 |
| control + 1 | 88.9 | 40 *** | 90.8 | 75 *** | |
| 430 | 31.1 | nd 2 | 51.2 | 17 ** | |
| 215 | 79.2 | 9 * | 99.9 | 12 * | |
| 107 | 69.8 | 4 | 96.2 | 4 | |
| 53.7 | 80.3 | 3 | 111 | nd 2 | |
| with metabolic activation (S9 mix) | untreated | 100 | 3 | ||
| control + 3 | 85.1 | 239 *** | |||
| 773 | 127 | 4 | |||
| 387 | 145 | 2 | |||
| 193 | 119 | 3 | |||
1 without metabolic activation: Positive control is Mitomycin C at 0.05 and 0.025 µg/mL, without and with recovery, respectively. 2 not determined. 3 with metabolic activation: Positive control is Cyclophosphamide at 10 µg/mL. * p < 0.05, ** p < 0.01, *** p < 0.001 versus untreated.