Figure 3.

Piper genus-derived compounds exhibit cytotoxic effects in cancer and non-transformed human cells. (A) PC-3/A549 cells were treated with increasing concentrations of eriopodol A and erioquinol while (B) human umbilical vein endothelial cells (HUVEC)/MCF10 cells were treated with increasing concentrations of gibbilimbol B, eriopodol A, and erioquinol, for 24 h before 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Results are expressed by setting the absorbance of the reduced MTT in the respective control (vehicle-treated) samples, i.e., absence of compounds, as 100%. The data points are representative of four independent experiments.