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. 2019 Aug 27;11(9):1257. doi: 10.3390/cancers11091257

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cytokine antibody array image and effect of cytokines on PD-L1 expression in lung cancer cell lines. (a) The array image showing osteoprotegerin (OPG), growth related oncogene (GRO) -α/β/γ (C-X-C motif chemokine ligand: CXCL1/2/3), and IL-8 in pFCS-1 (upper) and -2 (lower) CM with/without co-culture. Effect of CXCL2, IL-8, and OPG on PD-L1 mRNA level in A549 (b), PC-9 (c), and H1975 (d). (b) A549: CXCL2 100 ng/mL, IL-8 100 ng/mL, OPG 100 ng/mL; (c) PC-9 and (d) H1975: CXCL2 10 ng/mL, IL-8 10 ng/mL, OPG 50 ng/mL. (e) CXCL2 mRNA level in CAFs (pFSC-1 and pFSC-2) and normal lung fibroblasts (OUS-11). Data were presented as means ± SD from three independent experiments. * p < 0.05 vs. control. # 0.05 ≤ p < 0.1 vs. control.