Table 2.

Association between α-SMA status and clinicopathological parameters in 113 lung adenocarcinoma cases (cohort 2).

		Total	α-SMA	α-SMA	p-Value
			High	Low
Age	median	66	64.5	70	0.0872
(years)	max	82	80	82
	min	30	30	46
Sex	male	58	37	21	0.0241*
	female	55	23	32
Smoking	smoker	61	38	23	0.0391*
	never	52	22	30
Brinkman index	median	240	520	0†	0.0131*
	max	1920	1840	1920
	min	0	0	0
Size of tumor	median	25	24.5	27	0.2570
(mm)	max	80	80	70
	min	10	10	10
pStage	I	68	29	39	0.0022*
	II	13	7	6
	III	24	17	7
	IV	8	7	1
pT	1	65	34	31	0.7978
	2	36	19	17
	3	3	2	1
	4	9	5	4
pN	0	85	38	47	0.0015*
	1	8	6	2
	2	19	15	4
	3	1	1	0
cM	0	105	53	52	0.0648#
	1	8	7	1
PD-L1	positive	17	17	0	<0.0001*
	negative	96	43	53

* p-value < 0.05, #0.05 ≤ p-value < 0.1, †The great majority of the patients were never-smokers in our present study.