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. 2019 Sep 5;8(9):1035. doi: 10.3390/cells8091035

Figure 2.

Figure 2

Conserved domains and motifs of Kre33. (A) Representation of yeast Kre33 highlighting the conserved domains/motifs. From left to right, the N-terminal extension (NTE), containing putative nuclear localization signal (NLS) and nucleolar localization signal (NoLS) motifs, colored in dark blue and magenta, respectively. Overlapping NLS and NoLS regions are shown in purple. The NTE is followed by a domain of unknown function called DUF1726 (light blue), a helicase domain (blue), three TmcA-specific motifs (TS1, TS2 and TS3) colored respectively in light green, dark green and yellow, a N-acetyltransferase domain (orange) and a possible tRNA-binding domain (paprika). These highly conserved domains precede a C-terminal extension (CTE) harboring a putative coiled-coil motif (red) followed by the NLS (blue) and NoLS (magenta), with overlapping regions in purple. Point mutations generated by Sharma et al. [22] are indicated. (B) Tridimensional representation of bacterial TmcA and yeast Kre33. Structures were modeled with I-TASSER [101]. Conserved motifs were colored using PyMOL with the color code used in (A).