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. 2019 Sep 5;8(9):1035. doi: 10.3390/cells8091035

Figure 4.

Figure 4

Hypothetical model for Kre33 acetylation of RNAs. In the nucleolus, the Kre33 homodimer and Enp2 protein may interact together via their C-terminal coiled-coil motifs (in red) before joining the SSU processome. In this particle, Kre33 catalyzes the acetylation of two 18S rRNA cytosines: each modification is guided by a different box C/D small nucleolar RNA (snoRNA), snR4 (C1280 in helix 34) and snR45 (C1773 in helix 45). Acetylation of tRNAs and mRNAs could occur in the nucleoplasm, where Kre33 needs to interacts with the adaptor protein Tan1 in order to acetylate tRNAs. It is not known if acetylation of mRNAs requires adaptor protein(s). Nevertheless, it remains possible that acetylation of tRNAs and mRNAs could take place in the nucleolus since tRNAs and mRNAs have previously been detected in this compartment [51,54,91,92].