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. 2019 Sep 7;11(9):1328. doi: 10.3390/cancers11091328

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Anthracyclines reduce A23187- and Ionomycin- induced, Nox-independent NETosis in a dose-dependent manner. Neutrophils were activated with either A23187 (4 μM) or ionomycin (1 μM) to induce Nox-independent NETosis. NETosis kinetics estimated as earlier. A23187 and ionomycin induced NETosis suppressed by (A,E) epirubicin, (B,F) daunorubicin, (C,G) doxorubicin, and (D,H) idarubicin in a dose-dependent manner, respectively, (n = 3, * p < 0.05 between 10.0, 5.0 and 0.0 μM dosage with A23187 or ionomycin; Two-way ANOVA with Bonferroni’s multiple-comparison post-test).