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View full-text article in PMC

. 2019 Sep 7;11(9):1328. doi: 10.3390/cancers11091328

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Diagrammatic illustration shows NETosis regulation by anthracyclines. Neutrophils activated either with NOX-dependent (agonists; PMA, LPS) or -independent (agonists; A23187, Ionomycin) induces NETs release through the activation of respective ROS, kinases, and transcriptional firing. Anthracycline compounds intercalate between DNA base pairs and stop the unwinding, decondensation and transcriptional firing to stop the NETosis. Since this step is downstream of the ROS, these drugs are helpful in suppressing the NETs release with maintaining the neutrophils ROS generation capacity.