Table 1.
Anthropometric and metabolic effects in patients with obesity and type 2 diabetes (T2D) before and after Roux-en-Y gastric bypass (RYGB).
| Characteristics | Before Surgery | After Surgery |
|---|---|---|
| n (males, females) | 25 (11, 14) | 25 (11, 14) |
| Age (years) | 50 ± 2 | 51 ± 2 |
| BMI (kg/m2) | 44.2 ± 1.3 | 33.6 ± 1.6 *** |
| Body fat (%) | 49.9 ± 1.5 | 39.6 ± 2.0 *** |
| Waist (cm) | 128 ± 3 | 107 ± 3 *** |
| Waist-to-hip ratio | 1.00 ± 0.01 | 0.97 ± 0.02 ** |
| SBP (mmHg) | 128 ± 3 | 120 ± 3 ** |
| DBP (mmHg) | 80 ± 2 | 73 ± 1 *** |
| Fasting glucose (mg/dL) | 133 ± 7 | 115 ± 9 |
| Fasting insulin (μU/mL) | 21.3 ± 2.5 | 8.0 ± 1.2 *** |
| HOMA | 6.6 ± 0.8 | 2.1 ± 0.3 *** |
| QUICKI | 0.302 ± 0.006 | 0.363 ± 0.010 *** |
| HbA1c (%) | 7.2 ± 0.2 | 6.4 ± 0.2 ** |
| Triglycerides (mg/dL) | 140 ± 10 | 97 ± 11 ** |
| Total cholesterol (mg/dL) | 185 ± 7 | 159 ± 7 * |
| LDL-cholesterol (mg/dL) | 111 ± 6 | 90 ± 5 * |
| HDL-cholesterol (mg/dL) | 46 ± 2 | 51 ± 2 * |
| Leptin (ng/mL) | 45.3 ± 5.6 | 15.1 ± 2.4 *** |
| Adiponectin (µg/mL) | 6.73 ± 0.67 | 11.68 ± 0.81 *** |
| Adpn/Lep ratio | 0.21 ± 0.03 | 1.20 ± 0.19 *** |
| Uric acid (mg/dL) | 5.8 ± 0.3 | 4.5 ± 0.2 *** |
| Creatinine (mg/dL) | 0.80 ± 0.04 | 0.77 ± 0.03 * |
| CRP (mg/L) | 8.5 ± 1.6 | 2.1 ± 1.0 * |
| Fibrinogen (mg/dL) | 385 ± 21 | 348 ± 23 |
| von Willebrand factor (%) | 152 ± 11 | 138 ± 14 |
| Homocysteine (μmol/L) | 10.2 ± 1.2 | 9.3 ± 1.1 |
| AST (IU/L) | 15 ± 1 | 18 ± 2 |
| ALT (IU/L) | 21 ± 2 | 27 ± 5 |
| AST/ALT | 0.78 ± 0.07 | 0.87± 0.07 |
| γ-GT (IU/L) | 35 ± 6 | 16 ± 2 ** |
Adpn/Lep, adiponectin/leptin ratio; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; CRP, C-reactive protein; DBP, diastolic blood pressure; γ-GT, γ-glutamyltransferase; HbA1c, glycated hemoglobin; HOMA, homeostasis model assessment; NG, normoglycemic; QUICKI, quantitative insulin sensitivity check index; SBP, systolic blood pressure; T2D, type 2 diabetes. Data are mean ± SEM. Differences between groups were analyzed by two-paired Student t tests. * p < 0.05, ** p < 0.01, and *** p < 0.001 vs. before surgery.