Table 1.
Anti-enzymatic activities of pyroglutamic acid and sildenafil citrate against the human catalytic domain of phosphodiesterase-5A1.
| Inhibitor | IC50 (µM) |
|---|---|
| pGlu | 5.23 ± 1.33 |
| Sildenafil citrate | 7.14 ± 1.52 |
PRISM software version 8.0 (GraphPad Software, Inc., La Jolla, CA, USA) was used for statistical analysis. Values displayed are means ± standard deviation (SD) of three independent experiments achieved in triplicate. PDE5A1: Phosphodiesterase-5A1; pGlu: Pyroglutamic acid; IC50: Half-maximal inhibitory concentration.