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. 2019 Sep 10;20(18):4449. doi: 10.3390/ijms20184449

Figure 1.

Figure 1

(A–G): 8-oxo-dG stroma and epithelial staining in aged-matched histology groups across the Barrett’s esophagus disease spectrum. (A) Section of a core of Barrett’s intestinal metaplasia, at magnification 40×, demonstrating strong nuclear and cytoplasmic 8-oxo-dG staining in 100% of the glandular epithelium. (B) Section of a core of esophageal adenocarcinoma, at magnification 40×, showing moderate cytoplasmic staining in 100% of the epithelium, and weak to moderate cytoplasmic staining in 50% of the stroma cells and no nuclear staining. (C) Kruskal–Wallis analysis with Dunn’s multiple-comparison test demonstrated a significant increase in stroma cytoplasm positive for 8-oxo-dG in esophageal adenocarcinoma (EAC) compared with normal and high-grade dysplasia (HGD) patients. No significant difference was seen in 8-oxo-dG positivity in (D) stroma nuclei (p = 0.741), (E) epithelial cytoplasm (p = 0.763) and (F) epithelial nuclei (p = 0.697). * p < 0.05.