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(A–D): 4-HNE percentage positivity following normalization with Ki67. There were significantly increased levels of 4-HNE in SIM stroma (A) cytoplasm and (B) nuclei compared with EAC. No differences were demonstrated in 4-HNE levels in epithelial (C) cytoplasm (p = 0.200) and (D) nuclei (p = 0.974). * p < 0.05, *** p < 0.0005.
