Table 2.
The effect of OLP-01 on lactate levels during acute exercise challenge.
| Time Point | Vehicle | OLP1-01-1X | OLP-01-2X | OLP-01-5X | Trend Analysis |
|---|---|---|---|---|---|
| Lactate (mmol/L) | |||||
| Before swimming (A) | 3.42 ± 0.37 | 3.43 ± 0.36 | 3.41 ± 0.30 | 3.43 ± 0.24 | 0.7111 |
| After swimming (B) | 6.74 ± 0.28 b | 5.64 ± 0.57 a | 5.40 ± 0.83 a | 5.12 ± 0.59 a | <0.0001 |
| After a 20 min rest(C) | 6.05 ± 0.25 b | 5.04 ± 0.65 a | 4.76 ± 0.67 a | 4.53 ± 0.57 a | <0.0001 |
| Rate of lactate production and clearance | |||||
| Production rate = B/A | 1.99 ± 0.23 c | 1.64 ± 0.05 b | 1.58 ± 0.12 ab | 1.49 ± 0.10 a | <0.0001 |
| Clearance rate = (B − C)/B | 0.10 ± 0.02 | 0.11 ± 0.06 | 0.12 ± 0.03 | 0.12 ± 0.02 | 0.0222 |
The metabolite lactate was assessed for the four groups: vehicle, OLP-01-1X, OLP-01-2X, and OLP-01-5X at three time points. Lactate production rate (B/A) was calculated as the lactate level after exercise (B) divided by the lactate level before exercise (A). Clearance rate at rest (B − C)/B was defined as the difference in lactate levels immediately after exercise (B) and after rest (C), divided by lactate level after rest (B). Data are expressed as mean ± SD for n = 10 mice per group. Values in the same row with different superscript letters (a, b, c) differ significantly, p < 0.05.