Table 1.
miRNAs studied in animal models of diabetic neuropathy.
| miRNA | DN Model | Changes in DN | Target (s) | Reference (s) |
|---|---|---|---|---|
| miR-146a | DPN induced by intraperitoneal injection of STZ in HFD-fed rats | Down | IRAK1; TRAF6 | Feng Y et al., 2018 [49] |
| miR-146a | Db/db mice as model of T2D and DN | Down | IRAK1; TRAF6; ADAMTS3 | Liu XS et al., 2017 [52] |
| miR-146a | Db/db mice as model of T2D and DN | Down | IRAK1; TRAF6 | Wang L et al., 2014 [54] |
| miR-146a | Diabetes was induced in rats by a single-dose injection of nicotinammide followed by STZ | Up | IRAK1; TRAF6 | Yousefzadeh N et al., 2015 [55] |
| miR-106a | DPN model was established in mice following single injection of STZ | Down | 12/15-Lipoxygenase (12/15-LOX) | Wu Y et al., 2017 [56] |
| miR-155 | DN was established in rats following injection of STZ | Up | ND | El Lithy GM et al., 2016 [57] |
| miR-9 | DN was established in rats following injection of STZ | Up | CALHM1 is indirect target of miR-9 | Liu W et al., 2016 [58] |
| miR-466i | DPN was induced in mice following injection of STZ | Down | IL-1β; TNF-α; IL-6 | Gong Q et al., 2015 [59] |
| miR-467b | Down | |||
| miR-466a | Up | IL-1β | ||
| miR-128; miR-194; miR-466b; miR-98 | Up | IL-1β | ||
| miR-27a | Up | IL-10 | ||
| miR-194 | Up | IL-13 | ||
| 37 miRNAs were differently expressed in DRG | DN was established in rats following injection of STZ | 15 miRNAs were upregulated whereas 22 were downregulated | Podx1 and Hoxa1 were the most common targets | Guo G et al., 2018 [60] |
| miR-190-5p | DPN model was established in mice following single injection of STZ | Down | SLC17A6 | Yang D et al., 2017 [61] |
| miR-28, miR-31a and miR-130a | In vitro exosomes isolated from high glucose stimulated Swann Cells contained high levels of miRs-28, -31a, -130 | Up | NDNMT3A NUMB, SNAP25 and GAP43 | Jia L et al., 2018 [66] |
| miR-29b | DN was established in rats following injection of STZ | Down | TGF-β/Smad3 | Zhang X et al., 2014 [69] |
| Let-7i and miR-341 | DPN model was established in mice following single injection of STZ | Down | NF-kB | Cheng C et al., 2015 [71] |
DPN: Diabetic Peripheral Neuropathy; STZ: Streptozotocin; T2D: Type 2 Diabetes; IRAK1: Interleukin-1 receptor associated kinase 1; TRAF6: TNF-receptor associated factor 6; DRG: Dorsal root ganglion; NO: Nitric oxide; DH: Dorsal horn; ADAMTS3: A disintegrin and metalloproteinase with thrombospondin motifs 3; SLC17A6: Solute carrier family 17A6; CALHM1: Calcium homeostasis modulator 1; Podx1: Podocalyxin; Hoxa1: Homebox A1; NDNMT3A: DNA methyltransferase-3a; NUMB: an endocytic adaptor protein; SNAP25: Synaptosome associated protein 25; GAP43: Growth-associated protein-43; TGF-β: Transforming growth factor-β; Smad3: SMAD family member 3.