Table 3.
miRNAs involved in preclinical and clinical studies of diabetic neuropathy and the relative most regulated pathways.
| MiRNA | Target Genes | Most Regulated Pathways | KEGG Pathway |
|---|---|---|---|
| miR-146a | IRAK1 | NF-kB signaling pathway | mmu04064 |
| Toll-like receptor signaling pathway | mmu04620 | ||
| MAPK signaling pathway | mmu04010 | ||
| Neurotrophin signaling pathway | mmu04722 | ||
| miR-146a | TRAF6 | NF-kB signaling pathway | mmu04064 |
| Toll-like receptor signaling pathway | mmu04620 | ||
| Neurotrophin signaling pathway | mmu04722 | ||
| IL-17 signaling pathway | mmu04657 | ||
| NOD-like receptor signaling pathway | mmu04621 | ||
| MAPK signaling pathway | mmu04010 | ||
| Ubiquitin mediated proteolysis | mmu04120 | ||
| RIG-I-like receptor signaling | mmu04622 | ||
| Endocytosis | mmu04144 | ||
| miR-106a | 12/15-Lipoxygenase (12/15-LOX) | Arachidonic acid metabolism | mmu00590 |
| miR-190-5p | SLC17A6 | Synaptic vesicle cycle | mmu04721 |
| Glutamatergic synapse | mmu04724 | ||
| miR-31a; miR-130a |
NUMB; SNAP25 |
Notch signaling pathway | mmu04330 |
| Synaptic vesicle cycle | mmu04721 | ||
| Insulin secretion | mmu04911 | ||
| miR-29b | Smad3 | TGF-beta signaling pathway | mmu04350 |
| FoxO signaling pathway | mmu04068 | ||
| Wnt signaling pathway | mmu04310 | ||
| Th17 cell differentiation | mmu04659 | ||
| Cell cycle | mmu04110 | ||
| miR-29c | PRKCI | Tight junction | mmu04530 |
| Rap1 signaling pathway | mmu04015 | ||
| Endocytosis | mmu04144 | ||
| Insulin signaling pathway | mmu04910 | ||
| miR-466i; miR-467b | TNF-α; Il-6 |
NF-kB signaling pathway | mmu04064 |
| Apoptosis | mmu04210 | ||
| TNF signaling pathway | mmu04668 | ||
| HIF-1 signaling pathway | mmu04066 | ||
| PI3K-Akt signaling pathway | mmu04151 | ||
| Insulin resistance | mmu04931 | ||
| Toll-like receptor signaling pathway | mmu04620 | ||
| NOD-like receptor signaling pathway | mmu04621 | ||
| miR-466a; miR-128; -194; -466b; -98 |
IL-1β | NOD-like receptor signaling pathway | mmu04621 |
| NF-kB signaling pathway | mmu04064 | ||
| IL-17 signaling pathway | mmu04657 | ||
| Th17 cell differentiation | mmu04659 | ||
| Toll-like receptor signaling pathway | mmu04620 | ||
| Inflammatory mediator regulation of TRP channels | mmu04750 | ||
| miR-27; miR-194 | IL-10; IL-13 |
FoxO signaling pathway | mmu04068 |
| TCR signaling pathway | mmu04660 | ||
| IL-17 signaling pathway | mmu04657 | ||
| Th1 and Th2 cell differentiation | mmu04658 | ||
| miR-216a | ANGPTL4 | PPAR signaling pathway | hsa03320 |
| Cholesterol metabolism | hsa04979 | ||
| miR-217 | ADRBK2 GALM |
Glutamatergic synapse | hsa04724 |
| Glycolysis and gluconeogenesis | hsa00010 | ||
| Galactose metabolism | hsa00052 |
PRKCI: Isoform iota of Protein kinase C; MAPK: Mitogen-Activated Protein Kinase; FoxO: Forkhead Box O; HIF-1: Hypoxia Inducible Factor 1; PI3K: Phosphoinositide-3-kinase; ANGPTL4: Angiopoietin-like 4; ADRBK2: Beta-adrenergic receptor kinase 2; GALM: Gene encoding for Aldose 1-epimerase; PPAR: Peroxisome proliferator-activated receptor.