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. 2019 Sep 18;11(9):1394. doi: 10.3390/cancers11091394

Figure 1.

Figure 1

Immunohistochemical expression and survival analysis for the expression of interleukin4 receptor α (IL4Rα) and interleukin13 receptor α1 (IL13Rα1) in clear cell renal cell carcinoma (CCRCC). (A) Immunohistochemical expression of IL4Rα and IL13Rα1 in CCRCC tissue. Original magnification, ×400. (B) Analysis of sensitivity and specificity of the immunohistochemical staining score of IL4Rα and IL13Rα1 in CCRCC for the event of cancer-specific survival (death of the patient by CCRCC) by receiver operator characteristic curves. The cutoff points were determined at the highest area under the curve (AUC). Red arrow indicates a cutoff point for the IL4Rα immunostaining and blue arrowhead indicates a cut-off point for the IL13Rα1 immunostaining. (C) Kaplan-Meier survival analysis for cancer-specific survival and relapse-free survival according to the immunohistochemical positivity for IL4Rα and IL13Rα1 in 199 CCRCC. (D) Kaplan-Meier survival analysis in IL4Rα−/IL13Rα1−, IL4Rα−/IL13Rα1+, IL4Rα+/IL13Rα1−, and IL4Rα+/IL13Rα1+ subgroups according to the positivity for IL4Rα and IL13Rα1 expressions. (E) Kaplan-Meier survival analysis in two subgroups according to the co-expression patterns of IL4Rα and IL13Rα1; favorable (IL4Rα−/IL13Rα1−, IL4Rα−/IL13Rα1+, or IL4Rα+/IL13Rα1−) and poor prognostic (IL4Rα+/IL13Rα1+) subgroups. 5y-cancer-specific survival (CSS); 5-year cancer-specific survival rate, 10y-CSS; 10-year cancer-specific survival rate; 5y-RFS; five-year relapse-free survival rate, 10y- relapse-free survival (RFS); 10-year relapse-free survival rate.