Table 2.
Univariate Cox regression analysis of cancer-specific survival (CSS) and relapse-free survival (RFS) in clear cell renal cell carcinoma (CCRCC) patients.
| Characteristics | No. | CSS | RFS | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | ||
| Sex, male (vs. female) | 140 | 0.281 | 0.085–0.930 | 0.038 | 0.337 | 0.131–0.864 | 0.023 |
| Age, year, >55 (vs. ≤55) | 118 | 3.603 | 1.368–9.486 | 0.009 | 2.275 | 1.104–4.688 | 0.026 |
| Tumor size, >7 cm (vs. ≤7 cm) | 31 | 3.916 | 1.833–8.366 | <0.001 | 4.755 | 2.495–9.065 | <0.001 |
| TNM stage, I (vs. II–IV) | 37 | 4.044 | 1.922–8.509 | <0.001 | 5.354 | 2.831–10.124 | <0.001 |
| LN metastasis, presence (vs. absence) | 2 | 0.049 | 0–1.4 × 106 | 0.049 | 15.801 | 1.956–127.649 | 0.010 |
| Nuclear grade, 1 | 36 | 1 | 0.095 | 1 | 0.012 | ||
| 2 | 121 | 1.223 | 0.352–4.257 | 0.751 | 1.296 | 0.441–3.808 | 0.638 |
| 3 and 4 | 42 | 2.761 | 0.759–10.047 | 0.123 | 3.337 | 1.097–10.148 | 0.034 |
| Necrosis, presence (vs. absence) | 27 | 2.502 | 1.062–5.894 | 0.036 | 1.598 | 0.703–3.631 | 0.263 |
| IL4Rα positive (vs. negative) | 90 | 4.560 | 1.848–11.250 | <0.001 | 2.806 | 1.413–5.570 | 0.003 |
| IL13Rα1 positive (vs. negative) | 74 | 2.310 | 1.076–4.961 | 0.032 | 2.260 | 1.185–4.314 | 0.013 |
| IL4Rα/IL13Rα1, +/+ (vs. −/−, −/+, or +/−) | 52 | 3.748 | 1.771–7.933 | <0.001 | 3.467 | 1.833–6.557 | <0.001 |
HR: hazard ratios, CI: confidence interval, TNM: tumor-node-metastasis.