Table 3.
Multivariate Cox regression analysis of CSS and RFS in CCRCC patients.
| Characteristics | CSS | RFS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p | HR | 95% CI | p | |
| Model 1 * | ||||||
| TNM stage, I (vs. I–IV) | 3.603 | 1.706–7.607 | <0.001 | 5.246 | 2.773–9.925 | <0.001 |
| Necrosis, presence (vs. absence) | 2.407 | 1.003–5.777 | 0.049 | |||
| IL4Rα positive (vs. negative) | 4.334 | 1.753–10.713 | 0.001 | 2.727 | 1.372–5.422 | 0.004 |
| Model 2 ** | ||||||
| TNM stage, I (vs. II–IV) | 3.507 | 1.656–7.423 | 0.001 | 4.961 | 2.617–9.404 | <0.001 |
| IL4Rα/IL13Rα1, +/+ (vs. −/−, −/+, or +/−) | 3.286 | 1.542–7.000 | 0.002 | 3.158 | 1.662–6.000 | <0.001 |
* The variables included in the multivariate analysis model 1 were sex, age, tumor stage, histologic nuclear grade, tumor necrosis, and the expression of IL4Rα and IL13Rα1. ** The variables included in the multivariate analysis model 2 were sex, age, tumor stage, histologic nuclear grade, tumor necrosis, and co-expression patterns of IL4Rα and IL13Rα1.