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. 2019 Aug 29;11(9):1270. doi: 10.3390/cancers11091270

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Stepwise-clinical management of the patient with skeletal-metastasis of unknown primary (SMUP) suitable to individualized approaches. CT, computer-tomography; CK, cytokeratin; PSA, prostate-specific antigen; ER, estrogen receptor; PgR, progetseron receptor; CDX-2, caudal type homeobox 2; HEP PAR-1, hepatocyte specific antigen; TTF-1, thyroid transcription factor 1; NSE, neuron-specific enolase; AFP, α-fetoprotein; HCG, human chorionic gonadotropin; RT, radiotherapy; CHT, chemotherapy; IHC, immunohistochemistry. *: depending on performance status.