Table 1.
Bone metastases of unknown primary data overview and corresponding identified primaries and survival implications.
| Authors | SMUP at Diagnosis | Identified Primary Cancer | Number and Site of Primary Cancer Identified | Confirmed SMUP | mOS Confirmed SMUP (Months) |
|---|---|---|---|---|---|
| Simon and Karluk [10] | n = 12 |
n = 6 (50%) |
Kidney (3), lung (2), others (1) |
n = 6 (50%) |
NA |
| Simon and Bartucci [11] | n = 46 |
n = 20 (44%) |
Lung (7), kidney (6), breast = prostate (2), ovarian/thyroid/liver (1) | n = 26 (56%) | NA |
| Nottebaert et al. [12] | n = 51 |
n = 33 (65%) |
Lung (17), others (16) |
n = 18 (35%) |
11.1 |
| Shih et al. [13] | n = 52 |
n = 28 (54%) |
Lung (9), liver (8), kidney (5), prostate (3), thyroid (2), rectum (1) |
n = 24 (46%) |
11 |
| Rougraff et al. [14] | n = 40 |
n = 34 (85%) |
Lung (23), kidney (4), breast/colon/liver/ bladder (1), others (3) |
n = 6 (15%) |
NA |
| Jacobsen et al. [15] | n = 29 |
n = 24 (83%) (2 patients postmortem) |
Lung (11), prostate (3), breast/lymphomas (2), kidney/ovary/pancreas/stomach/small intestine carcinoid/retroperitoneal rhabdomyosarcoma (1) |
n = 5 (17%) |
12 |
| Katagiri et al. [16] | n = 64 |
n = 59 (92%) |
Lung (23), prostate (11), breast/liver (5), others (15) |
n = 5 (8%) |
5 |
| Vandecandelaere et al. [17] | n = 129 |
n = 84 (65%) |
Lung (36), prostate (17), kidney (15), breast (9), stomach (2), bladder/colon/testis/pancreas/liver (1) |
n = 45 (35%) |
6 |
| Destombe et al. [6] | n = 152 |
n = 94 (88%) |
Lung (37), prostate (26), breast (20), urinary system (11) |
n = 13 (12%) |
NA |
| Iizuka et al. [18] | n = 27 |
n = 26 (96%) |
Myeloma (7), lymphoma (3), lung (6), prostate (4), kidney/thyroid/liver/pancreas/stomach/esophagus (1) |
n = 1 (4%) |
NA |
| Hemminki et al. [8] | n = 501 |
n = 256 (60%) |
Lung (128), urinary (29), prostate (16), breast (14), colon (12), pancreas/gastrointestinal (10), liver (9), biliary system (4), stomach (3), mediastinum (2), others (19) |
n = 203 (40%) |
3 |
| Takagi et al. [9] | n = 286 |
n = 254 (89%) |
Lung (72), myeloma (41), prostate (26), lymphoma (23), kidney (18), liver (12), breast (12), gastric (10), pancreatic (10), thyroid (9), bile duct/colon (6), esophageal (3), others (6) |
n = 32 (11%) |
11 |
SMUP, skeletal metastasis of unknown primary; mOS, median overall-survival.