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. 2019 Sep 8;11(9):1330. doi: 10.3390/cancers11091330

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Oxaliplatin-induced apoptosis in (A) Caco-2 and (B) PANC-1 cells transfected with ABCC2-siRNAs and control-siRNA. The cells were treated with oxaliplatin (25 μM and 100 μM) for 2 h before stained with Annexin V-FITC/PI, and the rate of apoptosis was measured by flow cytometry. Data are presented as the mean of total apoptosis rate in percentage and standard errors of the mean of three independent experiments. Asterisks are P values (*, p < 0.05; **, p < 0.01; ***, p < 0.001) from Sidak post-tests that followed a two-way ANOVA.