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. 2019 Sep 5;20(18):4371. doi: 10.3390/ijms20184371

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The relationship between miRNAs and the genes regulated by them engaged in early chondrogenesis. ChiPS cells demonstrate markers for chondrogenic progenitors and upregulated expression of genes of early chondrogenesis (green color). Those genes are regulated by miRNAs whose expression decreases during chondrogenic differentiation (red color). The intensity of the used color of miRNAs and regulated genes was based on their fold change (FC) values (ChiPS vs. hiPSCs). miRNAs regulate sets of genes at the same time.