Table 1.
Clinico-pathological features and main molecular data of 16 IDH-wt GBMS in adult patients younger than 55 years. Cases are ordered by increasing TML.
| Case | Gender | Age | Site | OS (months) | IDH1/2 | EGFR | ATRX | TP53 | PTEN | TML | MMR Genes |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 GL | M | 49 | fronto-temporal right | DOD (11) | wt | ampl | 5.28 | ||||
| 6 GL | M | 41 | fronto-temporal right | DOD (3) | wt | ampl | 5.66 | ||||
| 2 GL | F | 49 | temporo-parietal left | DOD (46) | wt | ampl/mut | 6.34 | ||||
| 15 GL | M | 43 | fronto-basal | DOD (14) | wt | mut | 6.47 | ||||
| 16 GL | M | 40 | temporal left | DOD (9) | wt | mut | 7.12 | ||||
| 7 GL | M | 39 | temporo-parieto-occipital left | DOD (14) | wt | ampl | 7.33 | ||||
| 13 GL | F | 41 | temporal left | Alive (24) | wt | ampl | 7.75 | ||||
| 9 GL | M | 18 | temporo-parietal left | Alive (38) | wt | mut | mut | 8.22 | |||
| 11 GL | F | 29 | cerebellar right | DOD (15) | wt | 9.24 | |||||
| 10 GL | M | 43 | frontal | DOD (15) | wt | mut | mut | 10.1 | |||
| 8 GL | M | 46 | temporo-parietal left | Alive (41) | wt | mut | 12.35 | ||||
| 1 GL | F | 47 | temporo-parieto-occipital right | Alive (23) | wt | mut | mut | 13.07 | MLH1 mut * | ||
| 14 GL | M | 43 | frontal lobe | Alive (14) | wt | mut | 14.34 | ||||
| 3 GL | M | 24 | temporal left | Alive (24) | wt | ampl/mut | mut | 43.19 | |||
| 12 GL | M | 39 | frontal | Alive (32) | wt | mut | mut | 168.02 | MSH6 mut | ||
| 5 GL | F | 37 | frontal | Alive (79) | wt | mut | mut | 219.79 | MSH2 mut |
OS: overall survival. DOD: died of disease. TML: tumour mutation load. MMR: mismatch repair. F: female. M: male. Ampl: amplified. Mut: mutation. * Classified as benign in the PolyPhen Database.