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The nucleolar stress pathway. Nucleolus can be exposed to a variety of cellular stressors that disrupt ribosome biogenesis activating a complex cellular response namely “nucleolar stress”. This stress pathway is mediated by several ribosomal proteins RPs and/or nucleolar proteins and its activation results in cell cycle arrest, apoptosis, DNA damage and senescence. Dysregulation of this response is known to contribute to the development of cancer.
