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. 2019 Sep 5;8(9):375. doi: 10.3390/antiox8090375

Figure 12.

Figure 12

Immunoblot analysis of mutant p53, bax, Bcl-2, cleaved caspase-3, and cyclin D1 in control an experimental animal. 1-Control; 2-DMB; 3-DMBA+POL-PLGA-NPs (7.5 mg/kg b.wt.); 4-DMBA +POL-PLGA-NPs (15 mg/kg b.wt.); 5-DMBA +POL-PLGA-NPs (30 mg/kg b.wt.); 6-POL-PLGA-NP alone (30 mg/kg b.wt.). POL-PLGA-NPs enhance the apoptotic mediators such as Bax, cleaved caspase-3 and inhibit p53, Bcl-2 and cyclin-D1 expressions in a dose-dependent manner. Bar diagram represents the proteins expression; each bar represents the mean ± SD of three independent analysis.