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. 2019 Sep 12;20(18):4521. doi: 10.3390/ijms20184521

Figure 4.

Figure 4

Alignment of the amino acid sequences of AhR of insect species. The amino acid sequence of AhR of M. persicae shares a high level of homology with that of D. melanogaster. The conserved domains common to AhRs are boxed, including the basic helix-loop-helix (bHLH) and PER-ARNT-SIM (PAS) specific to AhR members. The bHLH region is involved in the binding of the transcription factor to DNA and facilitates protein-protein interactions. The PAS domains support specific secondary interactions with other PAS domain containing proteins, as is the case with AhR and ARNT. The glutamine-rich (Q-rich) domain is located in the C-terminal region of the protein and it is involved in co-activator recruitment and transactivation The AhR sequences of D. melanogaster were downloaded from Gene Bank with the accession number: AF050630, NM057400, NM001260211 and NM001170158. The AhR sequences of M. persicae were got from the transcriptome with the unigene number of c18023_g2_i1 and c18023_g2_i2 for AhR isofrom 1 and AhR isofrom 2, respectively (The clean reads obtained in this study were submitted to the NCBI/SRA database, SRA experiment accession number: SRX1499035).