Figure 8.

DNA methylation rate at the CpG site of CREB gene in rat hippocampus under various treatment conditions. The fragment containing nucleotide 56–470, with concentrated CpG sites, was selected as the target sequence. Abbreviated group names: CM—Saline-treated controls with Morris water maze training; CN—Saline-treated controls without Morris water maze training; AM—d-galactose injected rats received Morris water maze training; AN—d-galactose injected rats without Morris water maze training; S1M and S1N—Swimming exercise training before the d-galactose injection period with or without Morris water maze training; and S2M and S2N—Swimming exercise training during the d-galactose injection period with or without Morris water maze training.