Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 14;11(9):1368. doi: 10.3390/cancers11091368

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

EMT features in single circulating tumor cells (CTCs) and CTC clusters from a metastatic breast cancer patient. (a) Longitudinal monitoring of EMT features in CTCs. The Y-axis indicates the number of CTCs per 3 mL of blood. The patient was monitored over time (X-axis) during treatment with inhibitors targeting the PI3K and MEK pathways (months 1–8), followed by chemotherapy with Adriamycin (8–12). The color-coded quantification bars indicate the EMT status of the CTCs based on RNA-ISH (in situ hybridization) analysis at each indicated time point. P = disease progression; R = tumor response. (b) RNA-ISH analysis of EMT markers in CTCs derived from patients with metastatic breast cancer. Green dots represent epithelial (E) and red marks mesenchymal (M) markers. Scale bar: 5 µm. Adapted from [93].