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Event-free survival (EFS) among high-risk patients stratified by DHFR/MTHFR 677 gene variant. EFS at 5-years survey in patients carrying DHFR DD- or WD-genotype, and/or MTHFR TT-genotype (Any variant) vs. the remaining patients (Others). Panel (a) indicates EFS, as specified in Methods section; Panel (b) indicates EFS including prednisone response. The inclusion of the MTHFR A1298C variant, or its coupling with DHFR ins/del variant, did not modify survival analysis.
