Table 2.
Age of ALL (acute lymphoblastic leukemia) onset according to different children and mothers genotype.
| Genotype Groups | Onset Age in Children with That Genotype (Whole-Cohort) Mean ± SD; Median (n) [Range] |
P | Onset Age in Children with That Genotype (Dyad-group) Mean ± SD; Median (n) [Range] |
P | Onset Age in Children with Mother Carrying That Genotype Mean ± SD; Median (n) [Range] |
P | |
|---|---|---|---|---|---|---|---|
|
DHFR
ins/del |
WW | 5.2 ± 3.7; 4.07
(91) [0.003–16.6] |
0.002 a
0.0034 b 0.03 c |
4.8 ± 3.6; 3.8
(69) [0.003–16.6] |
0.007 a
0.0037 b 0.033 c |
5.8 ± 4.5; 3.92
(62) [0.7–16.6] |
ns a
ns b ns c |
| WD | 6.7 ± 4.4; 5.04
(108) [0.07–16.8] |
6.4 ± 4.5; 4.8
(78) [0.07–16.8] |
5.9 ± 4.1; 4.38
(81) [0.003–16.9] |
||||
| DD | 7.5 ± 4.8; 5.77
(36) [0.5–16.9] |
7.2 ± 4.7; 5.4 (22) [2.05–16.9] |
5.8 ± 4.3; 3.72
(26) [0.8–15.1] |
||||
|
MTHFR
677 |
CC | 6.4 ± 4.4; 4.66
(85) [0.5–16.7] |
ns a
ns b ns |
5.82 ± 4.3; 4.1
(50) [0.67–16.7] |
ns a
ns b ns c |
7.0 ± 5.3; 4.27
(46) [0.2–16.9] |
0.057 a 0.017 b ns c |
| CT | 6.2 ± 4.6; 5.23
(104) [0.003–16.9] |
6.21 ± 4.8; 4.04
(82) [0.003–16.9] |
5.5 ± 3.9; 4.09
(89) [0.068–16.8] |
||||
| TT | 5.5 ± 3.2; 4.5
(46) [0.77–15] |
5.19 ± 2.8; 4.4
(37) [0.77–11.6] |
5.4 ± 3.3; 4.07
(34) [0.003–11.7] |
||||
|
MTHFR
1298 |
AA | 5.78 ± 4.15; 4.07
(97) [0.48–16.9] |
0.006 a 0.005 b
0.05 c |
5.79 ± 4.21; 4.07
(71) [0.77–16.92] |
0.05 a 0.04 b ns c |
5.9 ± 4.1; 4.3 (88) [0.003–16.3] |
ns a
ns b ns c |
| AC | 5.96 ± 4.22; 4.49
(110) [0.003–16.8] |
5.76 ± 4.25; 4.21
(85) [0.0027–16.82] |
5.85 ± 4.4; 4.1
(67) [0.07–16.8] |
||||
| CC | 8.03 ± 4.82; 7.60
(28) [1.85–16.21] |
7.05 ± 4.84; 4.09
(13) [1.85–15.13] |
6.0 ± 4.7; 3.5
(14) [1.3–15.3] |
||||
Pa indicates comparisons performed between opposite genotype conditions by T-test (i.e., DHFR WW vs. DD; MTHFR 677 CC vs. TT, and MTHFR 1298 AA vs. CC); Pb indicates comparisons performed between DHFR D-allele carriers vs. WW-homozygotes (dominant model) and MTHFR 677 TT- or 1298 CC-homozygotes vs. the remaining genotypes (recessive model) by T-test; Pc indicates P-values adjusted for multiple testing.