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. 2019 Sep 1;9(9):431. doi: 10.3390/biom9090431

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes in cAMP accumulation in the SNr of animals that developed either mild or severe dyskinesia during L-DOPA treatment. (A,B) Synaptosomes obtained from animals in which L-DOPA treatment produced mild dyskinesia. (C,D) Synaptosomes obtained from animals in which L-DOPA treatment produced severe dyskinesia. Note: *** p < 0.001, comparison with the control; # p < 0.05, ## p < 0.01, and ### p < 0.001, comparison with SKF38393; ns = not significant between groups. Values mean ± standard error, n = 3 experiments, four replications per experiment.