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Distribution of leukocytes in gastric mucus of the NapA+LtB immunized mice (i–l). NZ-Δsp-napA+ltB group (n = 11) were challenged with H. pylori following gavages with mixture of NZ3900/pNZ-Δsp-napA and -sp-ltB. The gastric tissues were sampled from the mice 1 week after the challenges and examined via paraffin section and hematoxylin-eosin staining. Leukocytes including neutrophils, macrophages and lymphocytes accumulated in the deep and superficial mucosa and gastric mucus.
