. 2019 Sep 6;20(18):4378. doi: 10.3390/ijms20184378

Table 3.

PPARα polymorphisms and difference in fenofibrate response.

SNP	Lipid Changes
rs4253778 G > C (intron 7; G2528C) chr22:46234737 (GRCh38.p12)	(1) In patients with type 2 diabetes, the intron 7 G/G genotype was a significant predictor of TG response (OR: 3.10, 95% CI 1.28–7.52)
13 rare variants (minor allele frequency < 1%): - intronic variant 1 (35 base pairs upstream of exon 2) - rs4253793 (5′–UTR, in the first half of exon 3) - synonymous mutation (base pair location 44972983) - rs1042311 (missense mutation (alanine to valine) located in exon 7) - The remaining nine of the 13 rare variants were located in the 3′ UTR of PPAR. This region often contains sequences targeted by microRNAs	(1) Decreased TG response after three weeks of fenofibrate

SNP

Lipid Changes

rs4253778 G > C (intron 7; G2528C)
chr22:46234737 (GRCh38.p12)

(1) In patients with type 2 diabetes, the intron 7 G/G genotype was a significant predictor of TG response (OR: 3.10, 95% CI 1.28–7.52)

13 rare variants (minor allele frequency < 1%):
- intronic variant 1 (35 base pairs upstream of exon 2)
- rs4253793 (5′–UTR, in the first half of exon 3)
- synonymous mutation (base pair location 44972983)
- rs1042311 (missense mutation (alanine to valine) located in exon 7)
- The remaining nine of the 13 rare variants were located in the 3′ UTR of PPAR. This region often contains sequences targeted by microRNAs

(1) Decreased TG response after three weeks of fenofibrate