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Antinociceptive effect of JWH-018 (JWH), WIN 55,212-2 (WIN), LONI11 and vehicle (V, saline 0.1% v/v DMSO) at the dose of 10 µg/10 µL after intracerebroventricular (i.c.v.) administration in the tail flick test. The antinociceptive activity is expressed as percentage of the maximum possible effect (%MPE ± s.e.m.). * is for p < 0.05 and **** is for p < 0.0001 vs. V (vehicle-treated animals). N = 6.
