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. 2019 Sep 16;9(9):492. doi: 10.3390/biom9090492

Figure 5.

Figure 5

Effects induced in the early (white bars) and in the late (black bars) phase of the formalin test by vehicle (V, saline containing 0.9% NaCl in the ratio DMSO:saline 1:3 (v/v)), LONI11, WIN 55,212-2 and JWH-018 (JWH). The compounds were injected subcutaneously (s.c.) at a single dose (30–100 µg in 20 µL) 15 min before formalin injection (20 μL; s.c.). Early: Licking activity recorded from 0 to 10 min after formalin administration. Late: Licking activity recorded from 15 to 40 min after formalin administration. The results obtained are expressed as the mean ±S.E.M.; ** is for p < 0.01 and **** is for p < 0.0001 vs. V (vehicle-treated animals). N = 6.