Scheme 3.
Reagents and Conditions: (a) EDC·HCl (1.1 eq.), HOBt an. (1.1. eq.), NMM (3 eq.), methylamine 40% in water (2 eq.), DMF (6 mL), r.t. 12 h (LONI10: 96% yield; LONI11: 97% yield; LONI12: Quantitative).
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